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. 2014 Apr 16;9(4):e94756. doi: 10.1371/journal.pone.0094756

Figure 2. IL-7 and TLR7 synergistically increases CD4 T cell proliferation in T and B co-cultures.

Figure 2

Representative FACS stainings for KI67+ CD4 T cells from unstimulated, IL-7, and TLR7/IL-7 stimulated T/B cell co-cultures in the absence or presence of monocytes/macrophages are shown (n = 5). IL-7 significantly stimulates proliferation of CD4 T cells, which is synergistically increased when combined with TLR7 stimulation (A, B). IL-7-induced CD4 T cell proliferation is enhanced in the presence of monocytes/macrophages, but no additive effect is observed with a combination of IL-7 and TLR7 stimulation (C, D).*p<0.05 and **p<0.001 indicate statistical significance compared to medium values.