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. Author manuscript; available in PMC: 2014 Apr 16.
Published in final edited form as: J Pediatr. 2013 Jul 1;163(4):1147–51.e1. doi: 10.1016/j.jpeds.2013.05.038

Table I. Risk factors for developing FSE compared with simple FS.

Factor FSE N (%) Simple FS N (%) Univariate OR (95% CI) Multivariate OR (95% CI)
Age
 <18 mo 107 (63.3%) 40 (39.2%) 2.7 (1.6, 4.4) 2.8 (1.47, 5.43)
 ≥18 mo 62 (36.7%) 62 (60.8%) 1.0 (Referent) 1.0 (Referent)
Daycare attendance
 Daycare 32 (19.5%) 15 (15.3%) 1.3 (0.7, 2.6)
 No daycare 132 (80.5%) 83 (84.7%) 1.0 (Referent)
Drinking during pregnancy
 At least 1 drink in pregnancy 10 (6.3%) 1 (1.0%) 6.5 (0.8, 51.7)
 No drink in pregnancy 149 (93.7%) 97 (99.0%) 1.0 (Referent)
First-degree family history of FS
 Positive family history 42 (25.0%) 20 (20.2%) 1.3 (0.7, 2.4) 3.0 (1.28, 6.88)
 No family history 126 (75.0%) 79 (79.8%) 1.0 (Referent) 1.0 (Referent)
First-degree family history of epilepsy
 Positive family history 22 (13.1%) 8 (8.1%) 1.7 (0.7, 4.0)
 No family history Cpv 146 (86.9%) 91 (91.9%) 1.0 (Referent)
Sex
 Female 87 (51.5%) 43 (42.2%) 1.5 (0.9, 2.4) 2.2 (1.14, 4.43)
 Male 82 (48.5%) 59 (57.8%) 1.0 (Referent) 1.0 (Referent)
Premature birth
 ≤ 37 wk 46 (29.1%) 15 (15.5%) 2.2 (1.2, 4.3) 1.8 (0.82, 3.90)
 >37 wk 112 (70.9%) 82 (84.5%) 1.0 (Referent) 1.0 (Referent)
Smoking during pregnancy
 No 139 (82.2%) 94 (94.0%) 1.0 (Referent) 1.0 (Referent)
 Yes 30 (17.8%) 6 (6.0%) 3.4 (1.4, 8.4) 2.4 (0.77, 7.77)
Any temporal lobe abnormality other
  than increased T2 signal
 Abnormal 21 (13.0%) 3 (3.1%) 4.6 (1.3,16.0) 4.6 (1.17,18.33)
 No abnormality 140 (87.0%) 93 (96.9%) 1.0 (Referent) 1.0 (Referent)
Any structural abnormality on MRI
 Abnormal 60 (37.3%) 34 (35.4%) 1.1 (0.6, 1.8)
 No abnormality 101 (62.7%) 62 (64.6%) 1.0 (Referent)
Temperature
 <104.0°F 136 (81.0%) 57 (55.9%) 3.4 (1.9, 5.8) 3.7 (1.80, 7.50)
 ≥104.0°F 32 (19.0%) 45 (44.1%) 1.0 (Referent) 1.0 (Referent)
Time temperature was recognized before seizure
 1-24 h 139 (82.2%) 53 (53.0%) 2.2 (1.2, 4.2) 2.4 (1.10, 5.33)
 <1 h 28 (16.6%) 24 (24.0%) 1.0 (Referent) 1.0 (Referent)
 >24 h 2 (1.2%) 23 (23.0%) 0.1 (0.0, 0.3) 0.1 (0.01,0.56)