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(a) Mutant iPSCs injected intramuscularly into immune-deficient mice yielded well-differentiated cystic teratomas with a wide array of cell lineages encompassing cells of endodermal, mesodermal, and ectodermal origins. (b) Same in vivo pluripotentiality was observed in teratomas generated from the revertant iPSCs. Hematoxylin-eosin staining. Scale bar = 50 μm.
