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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Appl Microbiol Biotechnol. 2014 Feb 21;98(9):4075–4081. doi: 10.1007/s00253-014-5552-7

Figure 1. wzy-dependent pathway of lipopolysaccharide biosynthesis (E. coli O86:H2 O-polysaccharide as an example).

Figure 1

Biosynthesis is initiated with sequential assembly of repeat units on the cytoplasmic face of the inner membrane by glycosyltransferases (WbnH, WbnJ, WbnK and WbnI), after which translocation to the periplasmic face occurs. Polymerization of repeat units on the periplasmic face of the inner membrane then follows through the action of Wzy polymerase in a block transfer mechanism which is regulated by Wzz. The O-PS was transferred to lipid A core by WaaL to form the whole LPS which is then transported to outer membrane through Lpt pathway.