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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: J Invest Dermatol. 2013 Dec 10;134(5):1446–1455. doi: 10.1038/jid.2013.532

Figure 2. Ganglioside depletion accelerates wound healing in DIO mice.

Figure 2

GM3S−/− mice and wildtype (WT, GM3S+/+) on a regular (RD) or high fat (HFD) diet for 10 wks. (a) Representative image of ≥ 20 wounds each group and time point. (b) Computerized measurements of open wound area. Epidermal gap (c) and granulation tissue area (d) measured by computerized morphometry. (e) In vivo proliferation as number of BrdU-positive basal keratinocytes. (f) Basal keratinocyte migration as epidermal length from wound edge to first BrdU-positive cell. At least 20 sections were analyzed for BrdU detection (3 day wounds) for each mouse group. Data shown are means ± S.E. *p<0.05, ***p<0.001, for comparison of WT HFD vs. other mice and conditions, including GM3S−/− HFD.