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. Author manuscript; available in PMC: 2015 Apr 17.
Published in final edited form as: FEBS Lett. 2014 Feb 15;588(8):1322–1330. doi: 10.1016/j.febslet.2014.02.008

Figure 1.

Figure 1

One possible model of connexome organization. The gap junction is surrounded by the perinexus where Cx43 hemichannels interact with ZO-1, which regulates the transition of connexons to the gap junction. AnkG may be localized at the border of the perinexus restricting the plaque size. When AnkG is silenced (right panel), the perinexal area expands at the expense of the actual pore-forming gap junction. This yields to larger Cx43 plaques but a reduced channel-forming domain and gap junction conductance. From21 with permission.