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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Mol Cancer Res. 2014 Jan 27;12(4):550–559. doi: 10.1158/1541-7786.MCR-13-0458

Figure 4. Depletion of Mcl-1 abrogates TWEAK-induced protection from cell death induced by DNA damage.

Figure 4

H1975 cells were transfected with either siRNA targeting luciferase (control) or Mcl-1. Cells were exposed to 5uM cisplatin (A) or 8Gy radiation (B) for 0, 4 or 24 hours ± pre-incubation with TWEAK (100 ng/mL). Total cell lysates were prepared and immunblotted for cleaved-PARP (cPARP) and GAPDH as a loading control. All blots were run in duplicate.