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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Mol Cancer Res. 2014 Jan 27;12(4):550–559. doi: 10.1158/1541-7786.MCR-13-0458

Figure 6. Pharmacologic inhibition of Mcl-1 abrogates TWEAK-mediated cell survival.

Figure 6

H1975 (A and B) cells were pre-incubated with TWEAK (100 ng/mL), (A) EU-5148 (10 µM), (B) ABT-737 (10 µM) or both drug and TWEAK prior to exposure to 2Gy ionizing radiation. Cells were sparsely seeded (125 cells) into 6-well dishes and allowed to grow for 7 days prior to staining with crystal violet and colony counting. A colony was defined as containing at least 50 cells. Bars represent average of three independent wells ± standard error with the non-treated (first bar) set to 1. * represents a p value < 0.05 by ANOVA with Bonferroni posttest.