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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2014 Feb 3;7(2):313–320. doi: 10.1161/CIRCEP.113.000994

Figure 5.

Figure 5

Ca handling is impaired in isolated atrial myocytes (A, B) and intact atria (C–E) of Casq2−/− hearts. A and B left panels: Representative line scans of Ca sparks (A) and Ca waves (B) obtained in permeabilized atrial myocytes. Right panels: averaged data. N=35–45 cells per group, ***P<0.001. C) Examples of fluorescent Ca signals obtained from Ca maps of Casq2+/+ and Casq2−/− hearts. Casq2−/− atria frequently exhibit spontaneous Ca elevations (SCaE) after the rapid pacing train that are absent in Casq2+/+ atria (D). Similar to DADs, SCaE were observed only in some regions of the atria. E) Anatomical distribution of SCaE in intact atria.