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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2014 Feb 3;7(2):313–320. doi: 10.1161/CIRCEP.113.000994

Figure 7.

Figure 7

RyR2 channel block is necessary for prevention of pacing-induced SCaE and AF in Casq2−/− atria. (A) Representative examples of fluorescent Ca signals obtained from Ca maps of intact Casq2−/− hearts. As opposed to R-propafenone (R-Prop), administration of 3 μM of S-propafenone (S-Prop) or 20 μM of lidocaine (Lido) did not significantly reduce the rate (B) and amplitude (C) of SCaE in intact atria compared to vehicle. Despite a similar level of Na channel block evidenced by comparable QRS widening (D), S-propafenone and lidocaine failed to prevent AF in Casq2−/− hearts (E). N = 5–6 Casq2−/− hearts, **P<0.01.