Table 2.

Summary of mediation models predicting preclinical atherosclerosis with IL-6 as the mediator.

Regions of Interest	Total effect c Point est. (SE)	Direct effect c′ Point est. (SE)	Path a Point est. (SE)	Path b Point est. (SE)	Indirect effect a^* b
Regions of Interest	Total effect c Point est. (SE)	Direct effect c′ Point est. (SE)	Path a Point est. (SE)	Path b Point est. (SE)	Point est. (SE)	95% CI
dACC	.613^* (.243)	.484^* (.244)	.333^** (.128)	.387^* (.153)	.129^* (.108)	[.003, .429]
sgACC	.391 (.220)	.351 (.216)	.094 (.117)	.434^*** (.151)	.041 (.052)	[−.033, .185]
pgACC	.615^** (.236)	.499^* (.237)	.301^* (.125)	.389^* (.152)	.117 (.109)	[−.007, .435]
vmPFC	.462 (.275)	.314 (.275)	.355^* (.143)	.415^** (.154)	.147 (.123)	[−.003, .475]
amygdala	.486 (.262)	.380 (.259)	.254 (.138)	.417 (.152)^**	.106 (.098)	[−.008, .385]
DLPFC	.518 (.282)	.424 (.278)	.222 (.149)	.423^** (.152)	.094 (.116)	[−.028, .415]
vlPFC	.344 (.246)	.219 (.245)	.294^* (.128)	.425^** (.154)	.125 (.105)	[−.003, .419]
AI	.345 (.246)	.228 (.245)	.274^* (.129)	.426^** (.153)	.117 (.096)	[−.007, .383]

Note.

p<.05.

^**

p<.01.

^***

p<.005

Point est. (SE) = unstandardized point estimate with the corresponding standard errors in parentheses.

95% CI = Bias-corrected 95% confidence interval.

dACC, dorsal anterior cingulate cortex (ACC); sgACC, subgenual ACC; pgACC, perigenual ACC; vmPFC, ventromedial prefrontal cortex (PFC); DLPFC, dorsolateral PFC; vlPFC, ventrolateral PFC; AI, anterior insula (see Figure S1 for details regarding regions of interest).