Table 3.
Activities of peptide variants of PRX amide on the diapausing hormone receptor of Helicoverpa zea. See the Figure 1 for further details of AG (%), Lummodel2 (%), and Antagonist Index (ANT). The % values are comparative value to the activity of themodelligand (1737 GLWFGPRLa). The gaps of the aligned sequence by deletions are in the font crossed out. Gray box on amino acid sequence indicates the sequence scrambled.
| Chemical ID | Sequence information | AG (%) | ANT (%) |
|---|---|---|---|
| Truncated DH and deletion variants | |||
| 1739 |
|
98.1 | 1.2 |
| 1643 | WGFGPRLa | 112.8 | −13.5 |
| 1738 | LGLWGGPRLa | 104.6 | −5.9 |
| 1737 | LGLWFGPRLa | 102.4 | −4.3 |
| 1640 | LGLWFGPR La | 17.5 | 41 |
| 1673 | LGLWFGP RLa | 1.5 | 24.4 |
| 1674 | LGLWFG PR La | 2.6 | 14.6 |
| 1642 | LGLWFGPRLa | 54.7 | 13.3 |
| 1641 | LGLWFGPRLa | 3.2 | 26.2 |
| Pyrokinin 1 variants | |||
| 1765 | APFSPRLa | 104.8 | −5.0 |
| 1768 | FYAPFSPRLa | 106.6 | −6.8 |
| Capa variant | |||
| 1771B | FGNGLIPFPRVa | 3.0 | 15.9 |
| Alanine scan | |||
| 1619 | LWFGPRLa | 109.4 | −12.4 |
| 1615 |
|
116.7 | −24.1 |
| 1617 |
|
75.3 | 17.5 |
| 1618 |
|
83.1 | −2.4 |
| 1614 |
|
115.3 | −19.5 |
| 1620 |
|
73.1 | 14.2 |
| 1621 |
|
2.1 | 25.4 |
| 1622 |
|
12.3 | 26.1 |