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Nrg-1 heterocellular signalling: (A) Nrg heterocellular signalling between a coronary microvascular endothelial cell (top) and a cardiomyocyte (bottom). Scissor indicates proteolytic cleavage by metalloproteinases. The green box in (iv) indicates receptor phosphorylation and activation. (B) Nrg heterocellular signalling drives post-natal lobuloalveolar mammary gland changes upon pregnancy.
