Table 1.
Selected up- and down-regulated SCC invasion signature genes
| a. Selected up-regulated SCC invasion signature genes | |||||||
|---|---|---|---|---|---|---|---|
| Symbol | AK | SCC in situ | SCC invasion | Description | |||
| FCH | FDR | FCH | FDR | FCH | FDR | ||
| MMP12 | 1.14 | 0.90 | 2.31 | 0.37 | 32.97 | < 0.01 | matrix metallopeptidase 12 |
| PTHLH | 0.76 | 0.67 | 3.09 | 0.05 | 17.89 | < 0.01 | parathyroid hormone-like hormone |
| MMP3 | 1.19 | 0.89 | 4.77 | 0.15 | 16.38 | < 0.01 | matrix metallopeptidase 3 |
| AIM2 | 1.80 | 0.34 | 2.72 | 0.08 | 14.61 | < 0.01 | absent in melanoma 2 |
| NEFL | 0.87 | 0.83 | 2.23 | 0.13 | 13.34 | < 0.01 | neurofilament, light polypeptide |
| MMP13 | 0.96 | 0.95 | 2.37 | 0.11 | 12.53 | < 0.01 | matrix metallopeptidase 13 |
| KRT19 | 1.17 | 0.78 | 2.80 | 0.02 | 11.33 | < 0.01 | keratin 19 |
| INHBA | 0.86 | 0.80 | 2.42 | 0.07 | 10.89 | < 0.01 | inhibin, beta A |
| IL7R | 1.62 | 0.36 | 2.86 | 0.03 | 9.45 | < 0.01 | interleukin 7 receptor |
| CXCL10 | 3.63 | 0.24 | 5.26 | 0.11 | 9.44 | 0.02 | chemokine (C-X-C motif) ligand 10 |
| SPP1 | 1.45 | 0.70 | 2.18 | 0.37 | 8.76 | < 0.01 | secreted phosphoprotein 1 |
| PLAU | 2.60 | < 0.01 | 2.73 | < 0.01 | 8.45 | < 0.01 | plasminogen activator, urokinase |
| PDPN | 0.41 | 0.01 | 2.11 | 0.03 | 8.04 | < 0.01 | podoplanin |
| KRT18 | 2.24 | 0.16 | 2.80 | 0.06 | 7.69 | < 0.01 | keratin 18 |
| FN1 | 0.67 | 0.61 | 3.30 | 0.09 | 7.06 | < 0.01 | fibronectin 1 |
| APOBEC3G | 2.45 | 0.03 | 2.55 | 0.02 | 6.96 | < 0.01 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G |
| LAMC2 | 0.79 | 0.69 | 1.17 | 0.77 | 6.77 | < 0.01 | laminin, gamma 2 |
| IL24 | 1.20 | 0.79 | 2.03 | 0.23 | 6.74 | < 0.01 | interleukin 24 |
| CXCR4 | 2.60 | 0.09 | 1.78 | 0.31 | 6.16 | < 0.01 | chemokine (C-X-C motif) receptor 4 |
| MMP7 | 1.09 | 0.89 | 1.16 | 0.77 | 5.43 | < 0.01 | matrix metallopeptidase 7 |
| b. Selected down-regulated SCC invasion signature genes | |||||||
|---|---|---|---|---|---|---|---|
| AK | SCC in situ | SCC invasion | |||||
| Symbol | FCH | FDR | FCH | FDR | FCH | FDR | Description |
| TYRP1 | 0.79 | 0.88 | 0.45 | 0.54 | 0.03 | < 0.01 | tyrosinase-related protein 1 |
| FLG | 0.60 | 0.70 | 0.14 | 0.09 | 0.04 | < 0.01 | filaggrin |
| LOR | 1.39 | 0.80 | 0.25 | 0.21 | 0.07 | 0.01 | loricrin |
| TFAP2B | 1.17 | 0.83 | 0.36 | 0.10 | 0.07 | < 0.01 | transcription factor AP-2 beta |
| HPGD | 0.41 | 0.18 | 0.29 | 0.05 | 0.08 | < 0.01 | hydroxyprostaglandin dehydrogenase |
| DCT | 1.24 | 0.81 | 0.31 | 0.11 | 0.08 | < 0.01 | dopachrome tautomerase |
| NFIB | 0.61 | 0.38 | 0.36 | 0.04 | 0.10 | < 0.01 | nuclear factor I/B |
| CYorf15B | 0.40 | 0.38 | 0.23 | 0.12 | 0.11 | 0.02 | chromosome Y open reading frame 15B |
| DDAH1 | 1.18 | 0.74 | 0.73 | 0.50 | 0.12 | < 0.01 | dimethylarginine dimethylaminohydrolase 1 |
| CHI3L1 | 0.76 | 0.73 | 0.33 | 0.11 | 0.12 | < 0.01 | chitinase 3-like 1 |
| LCE2B | 1.15 | 0.87 | 0.25 | 0.05 | 0.13 | < 0.01 | late cornified envelope 2B |
| ANXA9 | 1.17 | 0.81 | 0.54 | 0.26 | 0.13 | < 0.01 | annexin A9 |
| NEB | 1.06 | 0.90 | 0.41 | 0.02 | 0.13 | < 0.01 | nebulin |
| ALOX12 | 1.26 | 0.47 | 0.38 | < 0.01 | 0.14 | < 0.01 | arachidonate 12-lipoxygenase |
| CEP76 | 0.46 | 0.09 | 0.40 | 0.04 | 0.14 | < 0.01 | centrosomal protein 76kDa |
| ACSBG1 | 0.93 | 0.89 | 0.38 | 0.02 | 0.15 | < 0.01 | acyl-CoA synthetase bubblegum family member 1 |
| KIT | 0.64 | 0.43 | 0.42 | 0.09 | 0.16 | < 0.01 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| NFASC | 0.38 | < 0.01 | 0.36 | 0.00 | 0.16 | < 0.01 | neurofascin homolog |
| AADAC | 1.34 | 0.54 | 0.47 | 0.08 | 0.16 | < 0.01 | arylacetamide deacetylase |
| ATP6V0E2 | 0.80 | 0.55 | 0.38 | 0.00 | 0.17 | < 0.01 | ATPase, H+ transporting V0 subunit e2 |