Chronic METH treatment induced the expression of HDACs (HDAC1, HDAC2, SIRT1 and SIRT2), REST, and CoREST proteins in the dorsal striatum. Chronic METH administration increased the protein levels of (A) HDAC1, (B) HDAC2, (C) SIRT1, (D) SIRT2, (E) REST, and (F) CoREST. Representative photomicrographs show results of three samples per group. For quantification, the signal intensity was normalized to 3-tubulin. Values represent means ± SEM of fold changes relative to the controls. Statistical significance was determined by un-paired Student’s t-test. Key to statistics: * p< 0.05; ** p< 0.01; *** p< 0.001 vs. control group.