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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Biol Psychiatry. 2013 Oct 16;76(1):47–56. doi: 10.1016/j.biopsych.2013.09.034

Figure 7.

Figure 7

Co-treatment with valproic acid (VPA) blocked the METH-induced decreases in (A) GluA1 mRNA, (B) GluA2 mRNA, and (C) GluN1 mRNA. Sodium valproate (300 mg/kg) was injected intraperitoneally twice a day 30 min prior to either saline or to METH injections. Drug administration, RNA extraction and RT-PCR of GluA1, GluA2 and GluN1 are as described in the text. The relative amounts of mRNA were normalized to OAZ1 and quantified. Values represent means ± SEM of fold changes relative to the controls. Statistical significance for the four groups (n=7–8 rats per group) were compared by two-way analysis of variance and Bonferroni correction. Key to statistics: * p< 0.05; ** p< 0.01 (Bonferroni).