Table 3.
Estimates carrier prevalence of each low frequency SNP and association with NAIT.
| Excess of paternal carriers per 1000 unresolved NAIT cases | Carrier prevalence per 1000 individuals | ||||
|---|---|---|---|---|---|
|
| |||||
| SNP | r* | P-value┼ | 95% CIǂ | p§ | 95% CI |
| HPA-4b | −3.7 | 0.934 | (−10, 3.7) | 3.6 | (0.7, 10.5) |
| HPA-6bw | −1.7 | 0.699 | (−8, 6.7) | 4.7 | (1.3, 12.0) |
| HPA-7bw | 0.0 | (−4, 6.8) | 0.0 | [0.0, 4.2) | |
| HPA-7cw | 0.0 | (−5.7, 9.3) | 0.0 | [0.0, 6.0) | |
| HPA-8bw | 1.8 | 0.126 | (−2.7, 10.8) | 0.0 | [0.0, 4.5) |
| HPA-9bw | 9.8 | 0.021 | (−0.2, 23.0) | 8.3 | (3.3, 17.0) |
| HPA-10bw | 0.0 | (−6.2, 9.1) | 0.0 | [0.0, 6.9) | |
| HPA-11bw | 0.0 | (−4.2, 7.8) | 0.0 | [0.0, 4.5) | |
| HPA-12bw | 0.0 | 0.5 | (−6.6, 9.2) | 4.9 | (1.3, 12.6) |
| HPA-13bw | −2.3 | 0.909 | (−7.5, 4.6) | 2.3 | (0.3, 8.1) |
| HPA-14bw | 0.0 | (−3.9, 6.8) | 0.0 | [0.0, 4.1) | |
| HPA-16bw | 0.0 | (−3.9, 6.8) | 0.0 | [0.0, 4.1) | |
| HPA-17bw | 0.0 | (−4.0, 6.7) | 0.0 | [0.0, 4.3) | |
| HPA-18bw | 0.0 | (−4.1, 6.4) | 0.0 | [0.0, 4.4) | |
| HPA-19bw | 0.0 | (−4.1, 6.6) | 0.0 | [0.0, 4.4) | |
| HPA-20bw | 0.0 | (−4.1, 6.6) | 0.0 | [0.0, 4.5) | |
| HPA-21bw | 1.8 | 0.188 | (−3.4, 10.7) | 1.2 | (0.0, 6.8) |
| HPA-22bw | 0.0 | (−4.3, 7.8) | 0.0 | [0.0, 4.5) | |
| HPA-23bw | 0.0 | (−4.3, 7.7) | 0.0 | [0.0, 4.5) | |
| HPA-24bw | 0.0 | (−5.1, 7.4) | 0.0 | [0.0, 5.8) | |
| HPA-25bw | 0.0 | (−3.9, 6.7) | 0.0 | [0.0. 4.1) | |
| HPA-26bw | 0.0 | (−5.7, 9.2) | 0.0 | [0.0, 6.1) | |
*
r is excess of fathers carriers compared to mother carriers.
┼
P-values test the hypothesis that the excess paternal prevalence is positive, and are based on an exact permutation test.
ǂ
The 95% CI does not completely match with the p-value, because it is a two-sided approximate interval, while the test is one-sided and exact.
§
p is carrier prevalence of each SNP per 1000 people.