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. 2014 Apr 10;5:159. doi: 10.3389/fimmu.2014.00159

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Copyright © 2014 Ferlazzo and Morandi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DCs subsets may differently affect NK cell function. Distinct DC subsets reflect different capability to promote NK cell function: IL-15 released by LC may promote NK cell proliferation; IL-12, mainly produced by CLEC9A⁺/BDCA3⁺ DCs and BDCA1⁺ DCs, induces IFN-γ release and subsequent Th1 polarization of T cells; NK cytolytic activity may be boosted by IFN-α secreted by pDCs and CLEC9A⁺/BDCA3⁺ DCs.