Figure 9.

Top panel. EGFR binds to the IQ motifs of IQGAP1 and restricts its localization to the basolateral membrane. Middle panel. In the absence of IQGAP1, EGFR is restricted to the basolateral membrane. However, NuMA and the +Tips of astral microtubules attach arbitrarily to the membrane, resulting in mitotic spindle missorientation. Bottom panel. EGF treatment activates the EGFR, resulting in receptor internalization via vesicles. The restriction of IQGAP1 to the basolateral membrane is subsequently lost and mitotic spindles appeared to be randomly orientated, favoring tubulogenesis.