Table 1.

Plasma ALT, ALP, and bile salt levels in mice 10 days or 3, 6, or 12 wk old

	Genotype	10 Days	3 Wk	6 Wk	12 Wk
ALT, IU/l	+/+	9.8 ± 4.3	14.2 ± 7.3	42.4 ± 7.1	41.8 ± 6.8
	+/−	7.2 ± 1.9	22.5 ± 9.5	52.3 ± 9.3	52.1 ± 17.0
	−/−	13.4 ± 5.1	27.7 ± 21.5	301.7 ± 90.1*	292.1 ± 89.3*
ALP, IU/l	+/+	339.0 ± 35.1	291.2 ± 93.7	172.9 ± 13.2	71.5 ± 5.7
	+/−	300.9 ± 34.8	258.9 ± 35.2	168.8 ± 13.0	76.4 ± 8.2
	−/−	326.3 ± 33.0	244.5 ± 41.8	408.0 ± 164.3*	199.6 ± 29.6*
Bile salts, μM	+/+	14.3 ± 2.1	4.9 ± 0.9	1.6 ± 0.9	16.9 ± 15.2
	+/−	14.9 ± 6.5	11.2 ± 8.3	1.9 ± 0.8	12.0 ± 8.9
	−/−	49.7 ± 25.2*	85.6 ± 17.4*	47.6 ± 25.4*	46.9 ± 16.3*

Values are means ± SD. Plasma alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were elevated in 6- and 12-wk but not 10-day and 3-wk Abcb4^−/− mice compared with wild-type (WT) and heterozygote controls. In contrast, plasma bile acids were elevated by 10 days after birth and at all ages thereafter in Abcb4^−/− mice. n = 5–7 for each group;

^*P < 0.01 to WT.