Table 1.
Quantitative characteristics of slow waves simulated by the six model variations
| RMP, mV |
Amplitude, mV | Half-Width, s | Frequency, min−1 |
|||
|---|---|---|---|---|---|---|
| Variation | Wild Type | Knockout | Wild Type | Wild Type | Wild Type | Knockout |
| High-Cl | ||||||
| NaV | −66.4 | −67.2 | 44.4 | 1.2 | 18.8 | 17.7 |
| NSV | −64.6 | −65.1 | 44.4 | 1.5 | 19.2 | 17.8 |
| NSCa | −65.3 | −65.1 | 41.9 | 1.1 | 15.7 | 19.1 |
| CaV | −65.1 | −63.2 | 48.8 | 0.6 | 9.6 | — |
| Low-Cl | ||||||
| NaV | −66.7 | −66.0 | 42.9 | 0.8 | 18.3 | 17.8 |
| NSCa | −67.2 | −65.0 | 47.6 | 0.8 | 14.9 | 21.3 |
RMP is the resting membrane potential; amplitude is the difference between resting membrane potential and peak slow wave potential; half-width is the duration of slow wave as measured at half of the amplitude; wild-type denotes the simulations using normal model variations; knockout denotes anoctamin 1 (Ano1) knockout simulations; V is voltage; NS is nonselective.