Table A1.

Parameter values common to all model variations

Parameter	Value	Reference
Cell constants
Cm	25 pF	21, 27
v	1 × 10−12 l	10
vcyto	0.7 × 10−12 l	10
ver	0.1 × 10−12 l	10
F	96 485 C/mol
R	8.314 J·mol−1·K−1
T	310.0 K
Plasma membrane current parameters
[Ca2+]o	2 mM	10, 16
[Cl−]o	166 mM	76
[K+]i	140 mM	67
[K+]o	5 mM	67
[Na+]i	30 mM	10
[Na+]o	140 mM	10
EK	−89.0 mV	C
ENa	41.2 mV	C
ENS	0 mV	30, 49
gSOC	0.1 nS
Cytosolic Ca2+ flux parameters
KSOC	200 μM	6, 57
KPMCA	0.1 μM
bc	0.01	14
IP3R parameters
P	0.5 μM	65
k1	4000 μM−1·s−1	65*
k2	2.0 μM−1·s−1	65*
k3	4000 μM−1·s−1	65*
k4	2.0 μM−1·s−1	65*
k5	200 μM−1·s−1	65*
k−1	520 s−1	65*
k−2	2.1 s−1	65*
k−3	3772 s−1	65*
k−4	0.29 s−1	65*
k−5	16.4 s−1	65*
kIPR	7.0 s−1
Jleak	0.01 s−1
SERCA pump parameters
Ve	80 μM/s
Ke	0.1 μM	65
Ano1 model parameters
EC50(0mV)	1.39 μM	70
kc	0.012 48 mV−1	70
Vh	−100 mV
kv	0.0156 mV−1	70
Ano1-SOC localization parameters
Dc	250 μm2/s	55
Dm	75 μm2/s	55
Km	1 μM	55
Bm	50 μM	55
r	0.05 μm
vscale	1015 μm3/l	C
nSOC	50	16

C denotes that the parameter value was calculated using other parameters; SERCA is sarco-endoplasmic reticulum ATPase; SOC is store-operated Ca²⁺ channel; see text for other definitions. References are given where available; other parameter values were chosen to reproduce correct slow wave activity.

^*Inositol 1,4,5-trisphosphate receptor (IP₃R) k_i values are double the values in Ref. 65 to reproduce correct Ca²⁺ oscillation frequency.