Table A2.
Parameter values that differ across model variations
| Parameter | Value | Reference |
|---|---|---|
| Cl− parameters | ||
| [Cl−]i | ||
| H | 78 mM | C |
| L | 25.85 mM | 76 |
| ECl | ||
| H | −20.2 mV | C |
| L | −49.7 mV | C |
| Ion channel maximal conductances | ||
| gAno1 | ||
| H(NSV,NSCa) | 20 nS | |
| H(NaV,CaV), L(NaV) | 15 nS | |
| L(NSCa) | 10 nS | |
| gCaT | ||
| H(NaV,NSV,CaV), L(NaV) | 3 nS | 10 |
| H(NSCa), L(NSCa) | 4 nS | |
| gKb | ||
| H(NSV,NSCa,CaV) | 9 nS | |
| H(NaV), L(NaV,NSCa) | 5 nS | |
| gNab | ||
| H(NSV,NSCa,CaV) | 2 nS | |
| H(NaV), L(NaV,NSCa) | 1 nS | |
| gNaV | ||
| H(NaV) | 6 nS | |
| L(NaV) | 10 nS | |
| gNSV | ||
| H(NSV) | 30 nS | |
| gNSCa | ||
| H(NSCa), L(NSCa) | 30 nS | |
| gCaV | ||
| H(CaV) | 6.2 nS | |
| gKt | ||
| L(NaV) | 6 nS | |
| gKERG | ||
| L(NaV) | 3 nS | |
| Ca2+ pump maximal fluxes | ||
| VPMCA | ||
| H(NaV,NSV), L(NaV) | 50 μM/s | |
| H(NSCa) | 100 μM/s | |
| H(CaV) | 1500 μM/s | |
| L(NSCa) | 110 μM/s | |
| VNCX | ||
| L(NSCa) | 225 μM/s |
C denotes that the parameter value was calculated using other parameters; see text for other definitions. References are given where available; other parameter values were chosen to reproduce correct slow wave activity. Model variations in which each parameter value is used are denoted by H for High-Cl and L for Low-Cl.