Table A3.
Gating variable parameters
| Variable | Vh, mV | K, mV | a | τx, s | Reference |
|---|---|---|---|---|---|
| dCaT | |||||
| H(NaV,NSV,CaV), L(NaV) | −26 | −6 | 1 | 0.006 | 10 |
| H(NSCa) | −40 | −3 | 1 | 0.006 | |
| L(NSCa) | −45 | −3 | 1 | 0.003 | |
| fCaT | |||||
| H(NaV,NSV,CaV), L(NaV) | −66 | 6 | 1 | 0.04 | 10 |
| H(NSCa), L(NSCa) | −55 | 5 | 1 | 0.1 | |
| dNaV | |||||
| H(NaV) | −25 | −5.6 | 1 | Eq. 40 | 3* |
| L(NaV) | −39 | −5.6 | 1 | Eq. 46 | 3 |
| fNaV | |||||
| L(NaV) | −55 | −4.5 | 0.53 | 1.0 | |
| dNSV | |||||
| H(NSV) | −30 | −5 | 1 | 0.005 | |
| fNSV | |||||
| H(NSV) | −50 | 5 | 0.3 | 0.8 | |
| dCaV | |||||
| H(CaV) | −26 | −6 | 1 | 0.006 | 10 |
| dKt | |||||
| L(NaV) | −20 | −4.6 | 1.0 | 0.003 | |
| fKt | |||||
| L(NaV) | −45 | 4.4 | 1.0 | 0.045 | |
| dKERG | |||||
| L(NaV) | −35 | −7.1 | 1.0 | Eq. 49 | |
| fKERG | |||||
| L(NaV) | −42 | 4 | 1.0 | 0.003 |
Parameters for voltage-dependent gating variables for x∞ = a/[1 + e(Vm − Vh/k)] + (1 − a) and for τx, where x = dCaT, fCaT, dNaV, fNaV, dCaV, dNSV, fNSV, dKt, fKt, dKERG, or fKERG. Model variations in which each parameter value is used are denoted by H for High-Cl and L for Low-Cl. References are given where available; other parameter values were chosen to reproduce correct slow wave activity; see text for other definitions.
*
Vh modified from values in Ref. 3.