Fig. 8.
Effects of different substrate (A) and strain application (B) on nitric oxide (NO) expression. A: NO expression is significantly higher on Matrigel than on NFs in WT and db groups (P < 0.05). Nω-nitro-l-arginine methyl ester hydrochloride (l-NAME), a potent inhibitor of NO synthesis does not play a significant role in capillary morphogenesis (bottom). B: application of strain significantly increases NO expression in LG and db groups, with a similar trend for the HG cells; in contrast, strain appears to have no effect on NO expression in the chronic HG group.