Fig. 9.

CCL2 deletion decreases hyperoxia-induced alveolar simplification and inflammatory cell trafficking. A: representative lung sections from CCL2^+/+ and CCL2-null mice exposed to normoxia or hyperoxia for 14 days were stained with hematoxylin and eosin. B: alveolar size, as measured by mean chord length, confirmed features noted on lung histology (n = 15–18 mice per group, *P <0.05, ANOVA). B: BAL cells were measured by Hemavet. Compared with hyperoxia-exposed CCL2^+/+ mice, CCL2-null mice tended to show decreased neutrophils (C) and macrophages (D). (n = 5–8 mice per group, means ± SE, *different from hyperoxia-exposed group, *P <0.05, ANOVA).