Table 2.
Top gene probes up- and downregulated when comparing BAT, subcutaneous WAT, and mesenteric WAT at thermoneutrality
| BAT 28°C vs. Subcutaneous 28°C Upregulated |
BAT 28°C vs. Subcutaneous 28°C Downregulated |
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|---|---|---|---|---|---|---|---|
| Gene symbol | FC | Adjusted P value | Gene name | Gene symbol | FC | Adjusted P value | Gene name |
| Zic1 | 111.91 | <0.001 | Zinc finger protein of the cerebellum 1 | Csn3 | 106.07 | <0.001 | Casein kappa |
| Cpn2 | 77.41 | <0.001 | Carboxypeptidase N, polypeptide 2 | Btn1a1 | 90.95 | <0.001 | Butyrophilin, subfamily 1, member A1 |
| Slc27a2 | 76.77 | <0.001 | Solute carrier family 27 (fatty acid transporter), member 2 | Foxa1 | 88.56 | <0.001 | Forkhead box A1 |
| 2310014F07Rik | 61.34 | <0.001 | RIKEN cDNA 2310014F07 gene | Areg | 82.96 | <0.001 | amphiregulin |
| Kng1 | 53.07 | <0.001 | Kininogen 1 | Ehf | 81.38 | <0.001 | Ets homologous factor |
| EG666481 | 44.08 | <0.001 | Predicted gene 8126 | Serpinb5 | 78.90 | <0.001 | Serpin peptidase inhibitor, clade B, member 5 |
| Olig1 | 42.44 | <0.001 | Oligodendrocyte transcription factor 1 | Cxcl15 | 78.77 | <0.001 | Chemokine (C-X-C motif) ligand 15 |
| Ppara | 40.04 | <0.001 | Peroxisome proliferator-activated receptor-α | Krt8 | 75.07 | <0.001 | keratin 8 |
| 9130214F15Rik | 38.03 | <0.001 | RIKEN cDNA 9130214F15 gene | Slc5a5 | 64.96 | <0.001 | Solute carrier family 5 (sodium iodide), member 5 |
| Chkb-cpt1b | 35.86 | <0.001 | Carnitine palmitoyltransferase 1b, muscle | Hoxa10 | 59.03 | <0.001 | homeobox A10 |
| BAT 28°C vs. Mesenteric 28°C Upregulated |
BAT 28°C vs. Mesenteric 28°C Downregulated |
||||||
|---|---|---|---|---|---|---|---|
| Gene symbol | FC | Adjusted P value | Gene name | Gene symbol | FC | Adjusted P value | Gene name |
| Ucp1 | 210.01 | <0.001 | Uncoupling protein 1 | Upk3b | 108.35 | <0.001 | Uroplakin 3b |
| Slc27a2 | 171.79 | <0.001 | Solute carrier family 27 (fatty acid transporter), member 2 | Phox2b | 101.69 | <0.001 | Paired-like homeobox 2b |
| Zic1 | 138.04 | <0.001 | Zinc finger protein of the cerebellum 1 | Colec10 | 95.85 | <0.001 | Collectin subfamily member 10 |
| 2310014F07Rik | 124.87 | <0.001 | RIKEN cDNA 2310014F07 gene | Bnc1 | 91.40 | <0.001 | Basonuclin 1 |
| Cpn2 | 107.34 | <0.001 | Carboxypeptidase N, polypeptide 2 | Scg2 | 87.39 | <0.001 | Secretogranin II |
| Myo5c | 65.24 | <0.001 | myosin VC | Snap25 | 85.13 | <0.001 | synaptosomal-associated protein 25 |
| Myh4 | 64.22 | <0.001 | Myosin, heavy polypeptide 4, skeletal muscle | Isl1 | 81.38 | <0.001 | ISL1 transcription factor, LIM/homeodomain |
| EG666481 | 58.31 | <0.001 | Predicted gene 8126 | Rims1 | 78.79 | <0.001 | regulating synaptic membrane exocytosis 1 |
| Six1 | 50.30 | <0.001 | Sine oculis-related homeobox 1 homolog (Drosophila) | Calcb | 77.62 | <0.001 | calcitonin-related polypeptide, β |
| Chkb-cpt1b | 47.65 | <0.001 | Carnitine palmitoyltransferase 1b, muscle | Bcl11a | 74.34 | <0.001 | β-cell CLL/lymphoma 11A (zinc finger protein) |
| Subcutaneous 28°C vs. Mesenteric 28°C Upregulated |
Subcutaneus 28°C vs. Mesenteric 28°C Downregulated |
||||||
|---|---|---|---|---|---|---|---|
| Gene symbol | FC | Adjusted P value | Gene name | Gene symbol | FC | Adjusted P value | Gene name |
| Csn3 | 174.98 | <0.001 | Casein kappa | Rims1 | 339.50 | <0.001 | Regulating synaptic membrane exocytosis 1 |
| Areg | 169.91 | <0.001 | Amphiregulin | Upk3b | 263.18 | <0.001 | Uroplakin 3b |
| Foxa1 | 164.17 | <0.001 | Forkhead box A1 | Snap25 | 235.42 | <0.001 | Synaptosomal-associated protein 25 |
| Tcfap2c | 150.16 | <0.001 | Transcription factor AP-2, gamma | Scg2 | 152.72 | <0.001 | Secretogranin II |
| Cxcl15 | 116.61 | <0.001 | Chemokine (C-X-C motif) ligand 15 | Nmu | 142.19 | <0.001 | Neuromedin U |
| Muc15 | 113.45 | <0.001 | mucin 15 | Phox2b | 131.78 | <0.001 | Paired-like homeobox 2b |
| Btn1a1 | 113.12 | <0.001 | Butyrophilin, subfamily 1, member A1 | Colec10 | 130.78 | <0.001 | Collectin sub-family member 10 |
| Elf5 | 109.85 | <0.001 | E74-like factor 5 | Vip | 113.28 | <0.001 | Vasoactive intestinal polypeptide |
| Esrp1 | 98.22 | <0.001 | Epithelial splicing regulatory protein 1 | Gal | 99.00 | <0.001 | galanin |
| Tmprss2 | 79.11 | <0.001 | Transmembrane protease, serine 2 | Resp18 | 95.51 | <0.001 | Regulated endocrine-specific protein 18 |