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. 2014 Feb 14;306(8):H1182–H1191. doi: 10.1152/ajpheart.00954.2013

Fig. 5.

Fig. 5.

Inhibition of JNKs or ER stress pathway inhibits OPN-stimulated apoptosis. A: ARVMs were pretreated with SP600125 (SP; JNKs inhibitor) for 30 min followed by treatment with OPN for 24 h. Apoptosis was measured using TUNEL assay. *P < 0.05 vs. CTL; $P < 0.05 vs. OPN; n = 3–7. B: ARVMs were pretreated with salubrinal (SAL; ER stress inhibitor) or z-ATAD-FMK (z-ATAD; caspase-12 inhibitor) for 30 min followed by treatment with OPN for 24 h. Apoptosis was measured using TUNEL assay. *P < 0.05 vs. CTL; $P < 0.05 vs. OPN; n = 3–5.