Table 1.
HFD-Unt | HFD + Wheel Exercise | HFD + Low-Dose C Cilostazol (550 mg/kg HFD) | HFD + High-Dose Cilostazol (733 mg/kg HFD) | HFD + AT-1015 | HFD + Low-Dose R118 (244 mg/kg HFD) | HFD + High-Dose R118 (366 mg/kg HFD) | |
---|---|---|---|---|---|---|---|
Number of mice/group | 26 | 12 | 30 | 17 | 14 | 28 | 30 |
Pretreatment | 746 ± 46 | 735 ± 24 | 818 ± 50 | 845 ± 86 | 640 ± 43 | 852 ± 50 | 842 ± 63 |
6 wk posttreatment | 680 ± 41 | 5,216 ± 1,151† | 725 ± 50* | 674 ± 61 | 630 ± 53 | 927 ± 96 | 703 ± 42 |
16 wk posttreatment | 595 ± 43† | 4,913 ± 1,234† | 647 ± 44‡ | 644 ± 72 | 571 ± 43 | 826 ± 80 | 693 ± 52 |
Data are presented as means ± SE. The maximum time of the test was 9,000 s. HFD, high-fat diet. Data were analyzed by one-way ANOVA with repeated measures and Holm-Sidak's post hoc test (pretreatment vs. 6 wk; pretreatment vs. 16 wk).
P < 0.05,
P < 0.01, and
P < 0.001 vs. pretreatment.