Table 1.

Treadmill endurance capacity is maintained in mice treated with R118

	HFD-Unt	HFD + Wheel Exercise	HFD + Low-Dose C Cilostazol (550 mg/kg HFD)	HFD + High-Dose Cilostazol (733 mg/kg HFD)	HFD + AT-1015	HFD + Low-Dose R118 (244 mg/kg HFD)	HFD + High-Dose R118 (366 mg/kg HFD)
Number of mice/group	26	12	30	17	14	28	30
Pretreatment	746 ± 46	735 ± 24	818 ± 50	845 ± 86	640 ± 43	852 ± 50	842 ± 63
6 wk posttreatment	680 ± 41	5,216 ± 1,151†	725 ± 50*	674 ± 61	630 ± 53	927 ± 96	703 ± 42
16 wk posttreatment	595 ± 43†	4,913 ± 1,234†	647 ± 44‡	644 ± 72	571 ± 43	826 ± 80	693 ± 52

Data are presented as means ± SE. The maximum time of the test was 9,000 s. HFD, high-fat diet. Data were analyzed by one-way ANOVA with repeated measures and Holm-Sidak's post hoc test (pretreatment vs. 6 wk; pretreatment vs. 16 wk).

^*P < 0.05,

^†P < 0.01, and

^‡P < 0.001 vs. pretreatment.