Table 2.
Examples of TCM herb-related diseases and bioentities: proteins, genes, and gene products.
| Herb | Diseases | Number | Proteins | Genes | Gene products |
|---|---|---|---|---|---|
| Artemisia annua | Malaria | 58 | Hemoglobin subunit alpha, Lymphotoxin-beta | COL13A1, MMP9 | Apical constriction, apyrase activity, pseudohyphal growth |
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| Artemisia annua | Breast neoplasm | 9 | Sex hormone-binding globulin, Prolactin receptor | SHBG, PRLR | Protein complex assembly multichaperone pathway |
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| Aconitum carmichaelii | Hypertension | 179 | Mineralocorticoid receptor, endothelial Nitric oxide synthase | NR3C2, NOS3 | Ethanolamine-phosphate cytidylyltransferase activity, urate oxidase activity |
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| Aconitum carmichaelii | Arthritis | 13 | Endothelial Nitric oxide synthase, Uridine-cytidine kinase 2 | NOS3, UCK2 | Phospholipid biosynthetic process, ventral midline determination |
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| Ginkgo biloba | Alzheimer's disease | 161 | Urokinase-type plasminogen activator, Tumor necrosis factor | PLAU, TNF | Neurotransmitter: sodium symporter activity, pseudohyphal growth |
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| Ginkgo biloba | Atherosclerosis | 24 | Prostaglandin G/H synthase 1, Cytosolic phospholipase A2 | VEGFA, PLA2G4A | Peripheral nervous system development, high-density lipoprotein |
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| Salvia miltiorrhiza | Asthma | 92 | Phenylalanine-4-hydroxylase, Vascular endothelial growth factor A | PAH, VEGFA | Protein kinase C activity, type II intermediate filament associated protein |
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| Salvia miltiorrhiza | Parkinson's Disease | 104 | Mitochondrial Glutamate dehydrogenase 1, Estrogen receptor | GLUD1, ESR1 | Antigen processing and presentation following pinocytosis, tRNA wobble guanine modification |