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. 2014 May;349(2):348–354. doi: 10.1124/jpet.113.211706

Fig. 2.

Fig. 2.

The effect of long-term ABT-089 and ABT-107 on the behavior of mice during nicotine withdrawal in the NIH. Data are mean (± S.E.M.) of treatment groups composed of four to nine mice per group. (A) Mice were implanted with osmotic minipumps containing nicotine (Nic) or saline (Sal). After 2 weeks of treatment, minipumps were removed from half of the nicotine animals and replaced with a minipump containing ABT-089 or ABT-107. One week after minipump switch, minipumps were removed from half of the nicotine, ABT-089, and ABT-107 treatment groups to induce spontaneous withdrawal. (B) Animals were tested in the NIH and latency to consume in the novel environment 2 weeks after minipump switch and 1 week after removal of the second minipump was measured. Latency to consume in the novel environment 2 weeks after minipump exchange and 7-day withdrawal from nicotine is reported as mean latency ± S.E.M. †P < 0.05 compared with nicotine withdrawal on Novel Day. (n = 4–9).