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Nicotinic receptor regulation after long-term treatment with ABT-089. Homogenate-binding experiments with a saturating concentration of [3H]EB were performed on hippocampal, cortical, striatal, and thalamic tissues from animals treated long term with ABT-089 or saline for 2 weeks. Minipumps were removed from half of the ABT-089 animals to induce spontaneous withdrawal for 24 hours. Data are mean (±S.E.M.) of treatment groups (n = 7–8).
