Table 3.

Clusters of 100 mm³ or more with statistically significant T₂ alterations associated with Alzheimer’s disease, gross infarcts, and hippocampal sclerosis, with all three types of neuropathology considered simultaneously.

Cluster Identifier	Principal Location	Volume (mm3)	Mean T2 Alteration (ms)	Minimum P-Value (unadjusted)
AD-1 a	Temporal, occipital, and parietal WMb	11,320	+4.4	2.0 × 10−4
AD-2	Frontal WM	13,648	+3.1	1.5 × 10−3
AD-3	Edge of temporal lobe	114	−5.8	5.0 × 10−4
AD-4	Edge of temporal lobe	161	−5.6	2.1 × 10−3
AD-5	Edge of hippocampus	133	−5.4	1.3 × 10−3
AD-6	Caudate, globus pallidus, medial thalamus	594	−2.5	1.5 × 10−3
AD-7	Insula	263	−2.8	2.9 × 10−3
AD-8	Insula	311	−3.1	1.5 × 10−3
CGI-1 c	Widespread	76,716	+2.7	4.3 × 10−3
AGI-1 d	Frontal and parietal WM, putamen	19,581	+6.9	2.3 × 10−3
AGI-2	Frontal and parietal WM	774	+5.6	2.5 × 10−3
AGI-3	Occipital WM and GMb	141	+7.3	1.8 × 10−3
AGI-4	Occipital and parietal WM and GM	136	+8.1	7.5 × 10−4
AGI-5	Cingulum	110	+4.8	7.6 × 10−4
HS-1 e	Temporal stem WM	912	+6.7	1.2 × 10−4
HS-2	Hippocampus and parahippocampal WM	308	+6.2	1.3 × 10−4
HS-3	Edge of temporal lobe	123	−9.1	6.0 × 10−6

^aAD clusters relate to the association of T₂ with the global Alzheimer’s pathology score.

^bWM = white matter, GM = gray matter.

^cCGI cluster relates to the association of T₂ with the number of chronic gross infarcts.

^dAGI clusters relate to the association of T₂ with the number of acute gross infarcts.

^eHS clusters relate to the association of T₂ with the presence of hippocampal sclerosis.