Table 2. Replication of results from previous studies in non-Hispanic whites and blacks for plasma fibrinogen levels.
We compared results from our tests of association with plasma fibrinogen and all SNPs tested with the results from previous studies. Note that the coded allele may be different across studies. Abbreviations: Candidate gene Association Resource (CARe), Coronary Artery Risk Development in Young Adults (CARDIA), Rotterdam Study (RS), Framingham Heart Study (FHS), Cardiovascular Health Study (CHS), Atherosclerosis Rick in Communities Study (ARIC), Monitoring of Trends and Determinants of Cardiovascular Disease/Cooperative Health Research in the Region Augsburg (MONICA/KORA).
| Non-Hispanic White | |||||||||||||
| NHANES III |
CARe Wassel et al |
CARDIA Reiner et al |
RS/FHS/CHSs/ARIC / MONICA Wassel et al |
||||||||||
| SNP | Alleles | Coded Allele | β | P-value | Coded Allele | β | P-value | Coded Allele | β | P-value | Coded Allele | β | P-value |
| rs4220 | A/G | G | −0.08 | 2.10E-3 | A | 0.14 | 1.04E-34 | -- | -- | -- | G | −0.08 | 2.14E-27 |
| rs2070011 | A/G | G | 0.02 | 0.14 | -- | -- | -- | A | −3.82 | 0.005 | -- | -- | -- |
| rs6050 | A/G | G | −0.04 | 0.03 | -- | -- | -- | G | −7.04 | 0.001 | -- | -- | -- |
| rs1800788 | C/T | C | 0.04 | 0.10 | -- | -- | -- | T | −6.41 | 0.008 | -- | -- | -- |
| rs1049636 | C/T | C | 0.04 | 0.04 | -- | -- | -- | C | 6.16 | 0.003 | -- | -- | -- |
| rs2066861 | A/G | G | 0.05 | 0.01 | T | −0.06 | 4.18E-10 | -- | -- | -- | -- | -- | -- |
| Non-Hispanic White | |||||||||||||
| NHANES III |
CARe Wassel et al |
CARDIA Reiner et al |
|||||||||||
| SNP | Alleles | Coded Allele | β | P-value | Coded Allele | β | P-value | Coded Allele | β | P-value | |||
| rs2070017 | A/G | G | 0.07 | 0.07 | T | −0.16 | 4.82E-9 | A | decreased | NS | |||
| rs2066874 | A/G | G | −0.28 | 7.00 E-4 | C | −0.33 | 2.86E-11 | G | decreased | NS | |||
| rs6050 | A/G | G | 0.01 | 0.52 | -- | -- | -- | G | decreased | NS | |||
| rs6058 | G/T | G | 0.06 | 0.18 | T | −0.17 | 9.52E-7 | -- | -- | -- | |||