Table 3. Novel significant associations between the fibrinogen cluster and haematological traits in NHANES III.

Linear regressions adjusting for age, sex, BMI and smoking status were performed for 25 SNPs, assuming an additive genetic model for five hematological traits. Significant associations (p < 0.05) between the fibrinogen cluster variants and any one haematologic traits in any NHANES III population are shown.

SNP	Phenotype	Location/Gene	Coded Allele	Race/Ethnicity	N	BETA (95% CI)	SE	p- value
rs2227395	Plasma fibrinogen	Intron/ FGB	G	Non-Hispanic White	1391	−0.08 (−0.13, −0.03)	0.02	7.00E-04
rs2070022	Plassma fibrinogen	3′ UTR/ FGA	G	Mexican American	659	−0.07 (−0.13, −0.02)	0.03	1.06E-02
rs2066860	LN Triglycerides	Intron/ FGG	G	Mexican American	1005	0.13 (0.02, 0.24)	0.06	2.27E-02
rs1800792	LN Triglycerides	5′ flanking/FGG	G	Mexican American	1005	−0.03 (−0.06, −0.003)	0.01	2.84E-02
rs6050	Platelet Distribution Width	Thr312Ala/FGA	G	Non-Hispanic White	2270	−0.03 (−0.06, −0.001)	0.02	4.06E-02
rs2070017	Platelet Count	Intron/ FGA	G	Non-Hispanic Black	1624	−8.12 (−14.93, −1.31)	3.47	1.95E-02
rs1800792	Platelet Count	Promoter/ FGG	G	Mexican American	1663	−5.32 (−9.83, −0.81)	2.30	2.07E-02
rs4220	White blood cell count	Arg478Lys/FGB	G	Mexican American	1682	−0.28 (−0.48, −0.08)	0.10	6.20E-03
rs2227395	White blood cell count	Intron/ FBG	G	Mexican American	1682	−0.23 (−0.43, −0.04)	0.10	2.00E-02
rs2066879	Platelet Distribution Width	3’ near FGG	G	Non-Hispanic White	2,268	0.77 (0.15, 1.39)	0.32	2.00E-02
rs2227409	Mean Platelet Volume	Asn170His/FGB	C	Non-Hispanic Black	1,657	1.11 (0, 2.22)	0.57	5.00E-02
rs6063	Platelet Distribution Width	Gly191Arg/ FGG	G	Non-Hispanic Black	1,628	0.61 (0.06, 1.15)	0.28	3.00E-02
rs2227425	Platelet Distribution Width	3’UTR/FGB	G	Mexican Americans	1,661	1.14 (0.08, 2.21)	0.54	3.00E-02