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. Author manuscript; available in PMC: 2015 Apr 15.
Published in final edited form as: J Neuroimmunol. 2014 Feb 4;269(0):20–27. doi: 10.1016/j.jneuroim.2014.01.013

Figure 3. No effect of metyrapone treatment on hippocampal insulin sensitivity.

Figure 3

(A), Representative western blot showing insulin-evoked phosphorylation of the insulin receptor at tyrosine 1150 in protein extracts from hippocampal slices generated from mice in the indicated conditions. (B) Incubation of hippocampal slices with insulin (100nM) evoked substantially less phosphorylation of hippocampal insulin receptors in db/db mice, irrespective of glucocorticoid status. For all graphs, asterisk (*) indicates statistical significance at p<0.05 following 2×2 ANOVA, and error bars depict the s.e.m.