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. 2014 Apr 11;5:139. doi: 10.3389/fphys.2014.00139

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Copyright © 2014 Cea, Riquelme, Vargas, Urrutia and Sáez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exogenous ATP reverses the absence of potentiation of muscular contraction in Panx1 deficient mice. Potentiation of muscular contraction was induced by electrical transmural stimulation (0.03 Hz, 45 V, 100 ms stimuli duration) in isolated Soleus muscle from Pannexin 1 deficient mice (Panx1^−/−), and exogenous ATP was applied (200 μ M, final concentration, closed circles) after 65 twitches. Then, the muscle was rinsed during 2 min and the potentiation response was re-evaluated. In addition, the potentiation response with the same number of twitches was evaluated in absence of ATP and washout (open circles).