Figure 2.

Scheme for B cell development from HSCs to mature B cells. Successive stages and alternative lineages are indicated. Key transcription factors and chromatin regulators are shown according to their established requirement during the early B cell differentiation process. HSC, hematopoietic stem cell; MPP, multipotent progenitors; MEP, megakaryocyte–erythrocyte progenitors; LMPP, lymphoid-primed multipotent progenitors; ELP, early lymphoid progenitors; CMP, common myeloid progenitors, GMP, granulocyte–macrophage progenitors; CLP, common lymphoid progenitors; ALP, all lymphoid progenitors; BLP, B cell-biased lymphoid progenitor; Pro NK, progenitor natural killer cells; NK, natural killer cells. When a factor is required at multiple developmental stages, only the earliest stage has been indicated and only factors important for the early stages of hematopoietic or B cell development are depicted. For simplicity, only one model of myeloid versus lymphoid divergence is illustrated; the alternative routes are not shown here [reviewed in Ref. (14)].