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. 2014 Apr 11;5:156. doi: 10.3389/fimmu.2014.00156

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Copyright © 2014 Choukrallah and Matthias.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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An early B cell specification module. Schematized network of inter-dependent TFs regulating early B cell development. The scheme depicts TFs that have been implicated in the control of early B cell specification and/or commitment (for clarity, factors such as Spi-B, OBF1, or NF-KB, which are important at later stages of B cell development, are not depicted here). Direct positive regulation between two factors at the transcriptional level is indicated by the corresponding arrows. Note that the scheme does not imply biochemical interactions (e.g., complex formation) between the factors, although they may also take place in some cases.