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. 2014 Apr 11;8:107. doi: 10.3389/fncel.2014.00107

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Copyright © 2014 Andreska, Aufmkolk, Sauer and Blum.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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dSTORM image of BDNF granules within presynaptic glutamatergic terminals. (A) Epifluorescence image of a peripheral neurite of a hippocampal neuron (DIV 35) with strong labeling of BDNF (green) and vGlut (red). The inset in the overlay image (merge) represents the dSTORM image shown in (B). (B,C) Single BDNF+ granules with a mean diameter of 64 nm were preferentially located within the vGlut+ area, representing the glutamatergic presynapse. Almost 90% of the BDNF immunoreactivity is found to overlap with vGlut. (C) Black-white presentation of the BDNF granules from image (B). Single vesicles with a dense BDNF label are pointed out by arrows. These granules have a diameter in the range of 60–90 nm.