Table I.
Characteristics of the case-control studies considered in the meta-analysis.
| Authors (refs.) | Year | Ethnicity | Genotyping method | HWE | Control source | Demographic characteristics | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| Cases | Controls | ||||||
| Safarinejad et al (27) | 2011 | Iranian (Asian) | PCR-RFLP | 0.56 | HB | 158 bladder cancer patients, mean age: 62.7±10.6 years | 316 controls, mean age: 61.6±9.4 years |
| Chung et al (26) | 2010 | Chinese-Taiwan (Asian) | PCR-RFLP | 0.26 | HB | 150 bladder cancer patients, mean age: 65.3±1.1 years | 300 controls, mean age: 66.2±0.7 years |
| Cai et al (23) | 2009 | Chinese (Asian) | PCR-RFLP | 0.08 | HB | 312 bladder cancer patients, mean age: 63.1±11.3 years | 325 controls, mean age: 63.7±12.2 years |
| Rouissi et al (6) | 2009 | Tunisian (African) | PCR-RFLP | 0.49 | PB | 185 bladder cancer patients, mean age 67.5±9.7 years | 191 controls, mean age (match the case) |
| Wang et al (25) | 2009 | Chinese (Asian) | PCR-RFLP | 0.07 | HB | 239 bladder cancer patients, pack years <55 (n=42); 55–65 (77); >65 (n=120) | 250 controls, pack years <55 (n=45); 55–65 (n=81); >65 (n=124) |
| Moore et al (7) | 2007 | Spanish (European) | TaqMan and Golden Gate | 0.48 | HB | 1,150 bladder cancer patients, mean age: 66.0±10.0 years | 1,149 controls, mean age: 65.0±10.0 years |
| Karagas et al (21) | 2005 | USA (American) | PCR-RFLP | 0.70 | PB | 352 bladder cancer patients, pack years ≤40 (9); 41–55 (n=60); 56–70 (n=203); >70 (n=80) | 551 controls, pack years ≤40 (31); 41–55 (n=110); 56–70 (n=304); >70 (n=106) |
| Moore et al (19) | 2004 | Argentina (American) | PCR-RFLP | 0.29 | PB | 110 bladder cancer patients, mean age: 68.1 (range, 20–80 years) | 110 controls, mean age: 68.4 years (match the case) |
| Lin et al (5) | 2004 | USA (American) | PCR-RFLP | 0.07 | HB | 457 bladder cancer patients, mean age: 65.0 (range, 18–86 years) | 457 controls, mean age: 64.0 (range, 21–89 years) |
| Sanyal et al (20) | 2004 | Swedish (European) | PCR-RFLP | 0.82 | HB | 327 bladder cancer patients, mean age: 70.0 (range, 33–96 years) | 246 controls, mean age (match the case) |
| Kimura et al (18) | 2001 | Germany (European) | PCR-RFLP | 0.17 | HB | 165 bladder cancer patients, mean age: 67.4±11.5 years | 150 controls, mean age: 62.0±11.4 years |
HWE, Hardy-Weinberg equilibrium; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; HB, hospital-based; PB, population-based.