Table II.
Distribution of methylenetetrahydrofolate reductase (MTHFR) gene Ala222Val and Glu429Ala genotypes for bladder cancer patients and controls.
| Study (refs.) | Ethnicity | Ala222Val of MTHFR | Glu429Ala of MTHFR | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
||||||||||||||
| Sample size (case/control) | Case | Control | Sample size (case/control) | Case | Control | ||||||||||
|
|
|
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| AA | AV | VV | AA | AV | VV | GG | GA | AA | GG | GA | AA | ||||
| Safarinejad et al (27) | Iranian | 158/316 | 67 | 74 | 17 | 144 | 142 | 30 | 158/316 | 48 | 85 | 25 | 178 | 115 | 23 |
| Chung et al (26) | Chinese | 150/300 | 80 | 57 | 13 | 141 | 123 | 36 | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Cai et al (23) | Chinese | 312/325 | 82 | 169 | 61 | 113 | 170 | 42 | 312/325 | 215 | 91 | 6 | 226 | 92 | 7 |
| Rouissi et al (6) | Tunisian | 185/191 | 87 | 86 | 12 | 81 | 90 | 20 | 185/191 | 97 | 78 | 10 | 121 | 60 | 10 |
| Wang et al (25) | Chinese | 239/250 | 66 | 128 | 45 | 88 | 132 | 30 | 239/250 | 169 | 67 | 3 | 171 | 75 | 4 |
| Moore et al (7) | Spanish | 1,041/1,049 | 418 | 478 | 145 | 402 | 486 | 161 | 1,068/1,078 | 537 | 457 | 74 | 557 | 429 | 92 |
| Karagas et al (21) | American | 350/543 | 140 | 171 | 39 | 227 | 245 | 71 | 350/542 | 173 | 146 | 31 | 267 | 220 | 55 |
| Moore et al (19) | Argentina | 106/109 | 45 | 42 | 19 | 32 | 59 | 18 | 106/108 | 52 | 45 | 9 | 55 | 45 | 8 |
| Lin et al (5) | American | 448/448 | 199 | 197 | 52 | 218 | 177 | 53 | 448/447 | 219 | 199 | 30 | 213 | 197 | 37 |
| Sanyal et al (20) | Swedish | 309/246 | 173 | 113 | 23 | 121 | 102 | 23 | 311/245 | 145 | 133 | 33 | 110 | 111 | 24 |
| Kimura et al (18) | Germany | 165/150 | 70 | 80 | 15 | 65 | 73 | 12 | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AA, Ala/Ala; AV, Ala/Val; VV, Val/Val; GG, Glu/Glu; GA, Glu/Ala; N/A, not available.