Tracer	System	Parameter Measured	Results	Reference
PET ([15O]-H2O, [15C]-CO2)	Liver metastases	Perfusion	Comparing dynamic versus steady state methods, differentiation between tumor grades	[62]
PET ([15O]-H2O)	Breast tumors	Perfusion and distribution volume	Evaluated non-invasive AIF measurement and obtained better estimations of distribution volume	[63]
PET ([15O]-H2O, 18FDG)	NSCLC	Perfusion and tumor localization	Large interpatient variations, inaccurate estimation of perfusion	[64]
PET ([15O]-H2O, [15C]-CO)	Solid tumors	Perfusion and blood volume	Phase I dose-escalation study, perfusion and blood volume decreases in response to CA4P	[66]
PET ([15O]-H2O, [15C]-CO)	Solid/metastatic renal tumors	Perfusion and blood volume	Phase II study, insignificant decreases in perfusion and BV in response to razoxane	[67]
PET ([15O]-H2O)	Renal tumors	Perfusion and metabolism	Perfusion decreases in patients with stable disease in response to SU5416	[68]
PET ([15O]-H2O, [11C]-CO)	Breast tumors	Perfusion and blood volume	No significant association between perfusion and response to treatment; insignificant increase in blood volume in non-responding tumors	[69]
PET ([15O]-H2O)	Colorectal metastases	Perfusion	Enhanced delivery of 5-FU via carbogen and nicotinamide, significant increase in perfusion post-treatment	[70]
PET ([15O]-H2O, 18F-FMISO)	Brain tumors	Perfusion and hypoxia	Early uptake correlations between perfusion and hypoxia, no late uptake correlations	[71]
SPECT (IMP)	Brain tumors	Perfusion	Differentiation between perfusion of tumor and perfusion of normal tissue	[73]
SPECT (99mTc- HSA)	Liver tumors	Perfusion	Increased perfusion in tumor following infusion of epinephrine	[74]
SPECT (201TICI, 99mTc-HSA-D)	Brain metastases	Permeability and viability	Significant post-treatment reductions in permeability and viability	[76]
SPECT (99mTc- MIBI)	Soft tissue and bone tumors	Perfusion and MIBI uptake ratio	Perfusion and MIBI uptake ratio lower in benign versus malignant tumors, achievable predictive value of these parameters	[77]
SPECT (99mTc- HMPAO, IAZA)	SCLC, GM, brain metastases, prostate and head and neck tumors	Perfusion and hypoxia	Inverse correlation between perfusion and uptake of IAZA in all tumors but GM tumors	[78]