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. Author manuscript; available in PMC: 2014 Apr 17.
Published in final edited form as: Cancer Metastasis Rev. 2008 Dec;27(4):589–613. doi: 10.1007/s10555-008-9157-4
Tracer System Parameter Measured Results Reference
Sonovue® (microbubbles) Power Doppler US Percent intratumor contrast agent uptake Following RF ablation therapy, DUPC accurately estimated degree of vascularization in 80% of cases [98]
Levovist® (microbubbles) CEUS Tumor vascularity Post-contrast vascularity correlated well with histological assessment of vascularity [99]
Sonovue® (microbubbles) CEUS, conventional B-mode US, spiral CT Number of metastases CEUS outperformed conventional US and CT in its ability to accurately detect more metastatic lesions [100]
Sonovue® (microbubbles) CEUS, color Doppler US Enhancement timing & pattern (related to vascularity) Accurate differentiation between nonfunctional islet tumors and pancreatic carcinoma [101]
Sonovue® (microbubbles) CEUS Percent blood volume fraction, RBC velocity & perfusion Post-treatment changes in these parameters following treatment with thalidomide [102]