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Summary of HDAC regulation of cell cycle. HDACs promote cell cycle progression by repressing protein function via repression of gene transcription at the promoter level, and by direct deacetylation of key cell cycle regulators.
| Deacetylation of histones at promoter region | |
|---|---|
| Promoter/gene | HDAC |
| p21 | HDAC1, HDAC2, HDAC3, HDAC4 |
| Skp2 | HDAC3 |
| E2F/Rb | HDAC1, HDAC2, HDAC3 |
| Deacetylation of non-histone proteins | |
| Protein | HDAC |
| E2F | HDAC1 |
| p53 | HDAC1, Sirt1 |
