TABLE 3.

Results of the Cox Regression Model Examining Risks Associated With Nursing Home Admission in Patients With Probable Alzheimer’s Disease Taking Conventional or Atypical Antipsychotics^a

	Model 1			Model 2			Model 3
Variable	Hazard Ratio	95% CI	p	Hazard Ratio	95% CI	p	Hazard Ratio	95% CI	p
Conventional antipsychotics	2.21	1.68–2.90	<0.0001	2.27	1.71–3.01	<0.0001	1.30	0.95–1.79	0.10
Atypical antipsychotics	1.01	0.62–1.65	0.97	1.05	0.64–1.72	0.84	1.02	0.61–1.71	0.94
Age	1.00	0.99–1.01	0.93	0.99	0.98–1.01	0.30	1.00	0.98–1.01	0.59
Education	1.05	1.01–1.09	0.01	1.05	1.01–1.10	0.01	1.07	1.03–1.11	0.001
Gender	0.92	0.71–1.18	0.50	0.88	0.68–1.13	0.30	0.83	0.64–1.08	0.17
MMSE score	0.94	0.92–0.97	<0.0001	0.94	0.92–0.97	<0.0001	0.95	0.93–0.97	<0.0001
Extrapyramidal signs				1.28	1.00–1.64	0.05	1.29	1.00–1.65	0.04
Incident stroke				1.01	0.68–1.52	0.94	0.87	0.58–1.33	0.52
Hypertension				1.07	0.83–1.39	0.58	1.16	0.90–1.51	0.25
Diabetes mellitus				1.21	0.77–1.90	0.41	1.22	0.77–1.93	0.40
Heart disease				1.52	1.09–2.12	0.01	1.57	1.12–2.20	0.009
Aggression							1.26	0.95–1.69	0.11
Agitation							1.35	1.01–1.79	0.04
Depression							1.06	0.75–1.49	0.75
Psychosis							1.56	1.19–2.04	0.001
Dementia medication							0.38	0.28–0.52	<0.0001

^aModel 1 controlled for age, education level, gender, and baseline Mini-Mental State Examination (MMSE) score. Model 2 included items from model 1 plus extrapyramidal signs, incident stroke, heart disease, diabetes mellitus, and hypertension. Model 3 included items from models 1 and 2 plus psychosis, depression, aggression, agitation, and dementia medication.