TABLE 4.

Results of the Cox Regression Model Examining Risks Associated With Death in Patients With Probable Alzheimer’s Disease Taking Conventional or Atypical Antipsychotics^a

	Model 1			Model 2			Model 3
Variable	Hazard Ratio	95% CI	p	Hazard Ratio	95% CI	p	Hazard Ratio	95% CI	p
Conventional antipsychotics	0.94	0.73–1.20	0.60	0.92	0.71–1.19	0.52	0.83	0.63–1.09	0.17
Atypical antipsychotics	1.10	0.77–1.59	0.60	1.20	0.83–1.74	0.32	1.02	0.69–1.50	0.93
Age	1.03	1.02–1.05	<0.0001	1.03	1.02–1.04	<0.0001	1.03	1.01–1.04	<0.0001
Education	1.05	1.01–1.09	0.007	1.06	1.02–1.10	0.002	1.06	1.02–1.10	0.002
Gender	1.53	1.23–1.89	<0.0001	1.50	1.21–1.88	<0.0001	1.48	1.19–1.85	0.001
MMSE score	0.93	0.92–0.95	<0.0001	0.94	0.92–0.96	<0.0001	0.94	0.92–0.96	<0.0001
Extrapyramidal signs				1.55	1.26–1.92	<0.0001	1.61	1.30–2.00	<0.0001
Incident stroke				1.32	0.95–1.84	0.10	1.22	0.87–1.72	0.24
Hypertension				1.16	0.93–1.43	0.18	1.15	0.92–1.42	0.21
Diabetes mellitus				1.45	0.99–2.13	0.05	1.39	0.94–2.06	0.10
Heart disease				0.90	0.67–1.21	0.48	0.90	0.67–1.22	0.50
Aggression							1.25	0.97–1.61	0.08
Agitation							0.99	0.77–1.26	0.91
Depression							1.26	0.95–1.67	0.11
Psychosis							1.26	1.00–1.59	0.04
Dementia medication							1.00	0.77–1.29	0.97

^aModel 1 controlled for age, education level, gender, and baseline Mini-Mental State Examination (MMSE) score. Model 2 included items from model 1 plus extrapyramidal signs, incident stroke, heart disease, diabetes mellitus, and hypertension. Model 3 included items from models 1 and 2 plus psychosis, depression, aggression, agitation, and dementia medication.