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. Author manuscript; available in PMC: 2014 Apr 17.
Published in final edited form as: Cancer Res. 2010 Sep 22;70(21):8863–8873. doi: 10.1158/0008-5472.CAN-10-1295

Figure 6. MELK function is required for Wnt1-induced tumorigenesis in vitro and in vivo.

Figure 6

Black bars = MELK shRNA, white bars = control shRNA, grey bar = MELK cDNA rescue. A and B, MELK shRNA reduced the frequency of tumorsphere-initiating cells in Wnt1 tumors. B, co-infection with virus expressing the MELK cDNA rescues tumorsphere proliferation; p < 0.05, n = 3. C, the percentage (%) of mCherry-positive cells in tumors (from D) after transduction with MELK shRNA is reduced compared to control shRNA. Unpaired t-test, p=0.0072.