| Receptor | AC Isoform | Cell line | Sensitization signal |
| D2L dopamine | Endogenous (AC6 and AC727) | CHO-D2L | 2-3 fold |
| D2L dopamine | Recombinant AC2, AC5, and AC6 | HEK 293 stably transfected | AC2 = 2-3 fold AC5 = 50 fold AC6 = 15 fold |
| μ opioid | Recombinant AC1, AC2, and AC5 | HEK 293 stably transfected | AC1 = 6-7 fold AC2 = 2-3 fold AC5 = 10-15 fold |
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